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A woman has a haemophilic son and three ...

A woman has a haemophilic son and three normal children . Her genotype and that of her husband with respect to this gene would be

A

`XX and X^(h)Y`

B

`X^(h)X^(h) and X^(h)Y`

C

`X^(h)X^(h) and XY`

D

`X^(h)X and XY`

Text Solution

AI Generated Solution

The correct Answer is:
To solve the problem of determining the genotypes of a woman with a hemophilic son and three normal children, we need to understand the inheritance pattern of hemophilia, which is an X-linked recessive disorder. Here’s a step-by-step breakdown of the solution: ### Step 1: Understand Hemophilia Hemophilia is an X-linked recessive disorder, which means that the gene responsible for hemophilia is located on the X chromosome. Males have one X and one Y chromosome (XY), while females have two X chromosomes (XX). ### Step 2: Determine the Son's Genotype Since the son is hemophilic, his genotype must be X^hY, where X^h represents the X chromosome carrying the hemophilia allele. The Y chromosome does not carry this gene. ### Step 3: Inheritance from Parents The son inherits his Y chromosome from his father and his X chromosome from his mother. Therefore, the mother must have contributed the X^h chromosome. ### Step 4: Determine the Mother's Genotype The mother has a hemophilic son and three normal children. This indicates that she must be a carrier of the hemophilia gene. Her genotype must be X^HX^h, where X^H represents the normal allele and X^h represents the hemophilia allele. This means she has one normal X chromosome and one X chromosome with the hemophilia allele. ### Step 5: Determine the Father's Genotype The father has three normal children and one hemophilic son. Since he has normal children, he cannot have the hemophilia allele. Thus, his genotype must be XY, indicating he has a normal X chromosome and a Y chromosome. ### Conclusion Based on the analysis, the genotypes of the parents are: - Mother: X^HX^h (carrier) - Father: XY (normal) ### Final Answer The genotypes of the woman and her husband with respect to this gene are: - Mother: X^HX^h - Father: XY
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