The correct order of sedimentation of subcellular structures during differential centrifugation is

Options

A. Lysosomes `rarr` Mitochondria `rarr` Nucleus `rarr` Ribosome
B. Nucleus `rarr` Mitochondria `rarr` Lysosomes `rarr` Ribosome
C. Mitochondria `rarr` Nucleus `rarr` Lysosomes `rarr` Ribosome
D. Ribosome `rarr` Mitochondria `rarr` Nucleus `rarr` Lysosomes

Answer

To determine the correct order of sedimentation of subcellular structures during differential centrifugation, we need to consider the size and density of these structures. The larger and denser the structure, the faster it will sediment when subjected to centrifugal force.

### Step-by-Step Solution:

1. **Understanding Differential Centrifugation**: In differential centrifugation, cellular components are separated based on their size and density. Larger and denser components sediment faster than smaller and less dense ones.

2. **Identifying Subcellular Structures**: The subcellular structures we need to consider are:
- Nucleus
- Mitochondria
- Lysosomes
- Ribosomes

3. **Ranking by Size and Density**:
- **Nucleus**: The largest and most dense among the listed structures. It sediments first.
- **Mitochondria**: Smaller than the nucleus but larger than lysosomes and ribosomes. It sediments second.
- **Lysosomes**: Smaller than mitochondria but larger than ribosomes. It sediments third.
- **Ribosomes**: The smallest and least dense structure among the four. It sediments last.

4. **Correct Order of Sedimentation**: Based on the above analysis, the correct order of sedimentation from first to last is:
- Nucleus
- Mitochondria
- Lysosomes
- Ribosomes

5. **Selecting the Correct Option**: Given the options, the second option correctly represents this order.

### Final Answer:
The correct order of sedimentation of subcellular structures during differential centrifugation is:
1. Nucleus
2. Mitochondria
3. Lysosomes
4. Ribosomes