Which of the following is incorrect about cancer ?

Options

A. Metastasis is seen only in the case of a malignant tumor.
B. The activation of c-onc genes leads to development of tumors.
C. The patient are given substances called biological response modifiers such as alpha-interferons which activates their immune system and helps in destroying the tumor.
D. None of the above

Answer

To determine which statement about cancer is incorrect, we will analyze each of the provided statements one by one.

### Step-by-Step Solution:

1. **Analyze the First Statement**:
- **Statement**: "Metastasis is seen only in case of malignant tumor."
- **Explanation**: Metastasis refers to the process where cancer cells spread from the original (primary) tumor to other parts of the body. This phenomenon is characteristic of malignant tumors, which are aggressive and can invade neighboring tissues and organs. In contrast, benign tumors do not metastasize; they remain localized.
- **Conclusion**: This statement is **correct**.

2. **Analyze the Second Statement**:
- **Statement**: "Activation of cancer oncogenes leads to development of tumors."
- **Explanation**: Oncogenes are mutated forms of proto-oncogenes, which are normal genes involved in cell growth and division. When these genes become activated (due to mutations or other factors), they can lead to uncontrolled cell proliferation and tumor formation.
- **Conclusion**: This statement is **correct**.

3. **Analyze the Third Statement**:
- **Statement**: "Patients are given substances called biological response modifiers such as alpha interferons which activate their immune system and help in destroying the tumor."
- **Explanation**: Alpha interferons are indeed biological response modifiers that enhance the immune response against tumors. They are used in cancer therapy to help the body fight against cancer cells by boosting the immune system's ability to recognize and destroy them.
- **Conclusion**: This statement is **correct**.

4. **Final Evaluation**:
- Since all three statements are correct, we look at the last option: "none of the above."
- This option suggests that there are no incorrect statements among the first three options.
- Therefore, the answer is that **none of the above statements are incorrect**.

### Final Answer:
**None of the above (Option D) is correct.**