Splitting of the centromere is a significance feature of

Options

A. Anaphase
B. Anaphase I
C. Anaphase II
D. Both (a) and (c)

Answer

To solve the question regarding the significance of the splitting of the centromere, we can break it down into the following steps:

### Step 1: Understand the Cell Cycle
The cell cycle consists of various stages, including interphase and two types of cell division: mitosis and meiosis. Each of these processes has specific phases where certain events occur.

**Hint:** Familiarize yourself with the stages of the cell cycle and what happens in each stage.

### Step 2: Identify the Types of Cell Division
There are two main types of cell division:
- **Mitosis:** This is an equational division where one cell divides to form two identical daughter cells.
- **Meiosis:** This is a reductional division that results in four genetically diverse gametes.

**Hint:** Remember the key differences between mitosis and meiosis.

### Step 3: Focus on Centromere Splitting
The centromere is the region of a chromosome where sister chromatids are joined. The splitting of the centromere is crucial for the separation of these chromatids during cell division.

**Hint:** Think about when and how the centromere splits in both mitosis and meiosis.

### Step 4: Analyze Mitosis
In mitosis, the splitting of the centromere occurs during **anaphase**. This is when the sister chromatids are pulled apart to opposite poles of the cell, resulting in two separate chromosomes.

**Hint:** Recall that anaphase is the stage where chromatids are separated.

### Step 5: Analyze Meiosis
In meiosis, the splitting of the centromere occurs during **anaphase II**. In anaphase I, homologous chromosomes are separated, but the sister chromatids remain attached. It is only in anaphase II that the centromeres split, allowing the sister chromatids to separate.

**Hint:** Differentiate between anaphase I and anaphase II in meiosis regarding centromere behavior.

### Step 6: Conclusion
Based on the analysis, the splitting of the centromere is a significant feature of **anaphase** in mitosis and **anaphase II** in meiosis. However, the question specifically asks for the significance feature, which is most commonly associated with mitosis.

**Final Answer:** The splitting of the centromere is a significant feature of **anaphase** in mitosis.