Which of the following is a quantitative diseases caused due to mutation of chromosome 11?

Options

A. Sickle - cell anemia
B. Phenylketonuria
C. Alpha thalassemia
D. Beta thalassemia

Answer

To solve the question regarding which of the following is a quantitative disease caused due to mutation of chromosome 11, we will analyze each option step by step.

### Step-by-Step Solution:

1. **Understanding the Question**:
We need to identify a quantitative disease linked to a mutation on chromosome 11. A quantitative disease is one where the quantity of a certain substance is affected, rather than its quality or structure.

2. **Analyzing the Options**:
- **Option 1: Sickle Cell Anemia**:
- This is a qualitative disease characterized by the abnormal shape of red blood cells (RBCs). It is caused by a mutation in the beta-globin gene, but it does not affect the quantity of hemoglobin produced. Therefore, this option is incorrect.

- **Option 2: Phenylketonuria (PKU)**:
- PKU is a metabolic disorder caused by a mutation in the PAH gene located on chromosome 12, not chromosome 11. While it is a quantitative disorder in terms of phenylalanine levels, it does not meet the criteria of being linked to chromosome 11. Thus, this option is also incorrect.

- **Option 3: Alpha Thalassemia**:
- Alpha thalassemia is indeed a quantitative disease as it involves a reduction in the production of alpha globin chains. However, it is caused by mutations on chromosome 16, not chromosome 11. Therefore, this option is incorrect as well.

- **Option 4: Beta Thalassemia**:
- Beta thalassemia is a quantitative disease caused by mutations in the HBB gene on chromosome 11. It results in reduced production of beta globin chains, affecting the quantity of hemoglobin. This matches the criteria of the question perfectly.

3. **Conclusion**:
After analyzing all the options, the correct answer is **Option D: Beta Thalassemia**. This is the only quantitative disease caused by a mutation on chromosome 11.

### Final Answer:
**Option D: Beta Thalassemia**