Which of the following condition arises in subsequent pregnancies after the first normal pregnancy ?

Options

A. Rh incompatibility disease
B. Erythroblastosis foetalis
C. Muscular dystrophy
D. Both (A) and (B)

Answer

To solve the question regarding the condition that arises in subsequent pregnancies after the first normal pregnancy, we can follow these steps:

### Step-by-Step Solution:

1. **Understanding Rh Factor**:
- The Rh factor is an antigen that can be present on the surface of red blood cells. Individuals with this antigen are classified as Rh positive (Rh+), while those without it are Rh negative (Rh-).

2. **First Pregnancy Scenario**:
- In the first pregnancy, if the mother is Rh- and the fetus is Rh+, the two blood types are generally separated by the placenta, preventing any mixing of blood.

3. **Exposure During Delivery**:
- During the delivery of the first child, there is a possibility that some Rh+ blood from the fetus can enter the mother's bloodstream. This exposure may lead the mother’s immune system to recognize the Rh antigen as foreign and produce antibodies against it.

4. **Subsequent Pregnancies**:
- In subsequent pregnancies, if the mother becomes pregnant again with another Rh+ fetus, the antibodies that were formed in response to the first exposure can cross the placenta and attack the red blood cells of the Rh+ fetus.

5. **Condition Resulting from Antibody Reaction**:
- This immune reaction can lead to a serious condition known as erythroblastosis fetalis (or hemolytic disease of the newborn), where the fetus suffers from severe anemia and jaundice due to the destruction of its red blood cells.

6. **Preventive Measures**:
- To prevent this condition, Rh- mothers are often given an injection of Rh immunoglobulin (RhIg) after the delivery of an Rh+ baby. This injection helps to prevent the formation of antibodies against Rh+ blood in future pregnancies.

### Final Answer:
The condition that arises in subsequent pregnancies after the first normal pregnancy in the case of Rh incompatibility is **erythroblastosis fetalis**.