All of the following factors are favourable for the formation of oxyhaemoglobin, except

Options

A. High pO2
B. Less H+ ions concentration
C. Low pH
D. Low Temperature

Answer

To determine which factor is not favorable for the formation of oxyhemoglobin, let's analyze the conditions that promote the formation of oxyhemoglobin (HbO2) from hemoglobin (Hb) and oxygen (O2).

### Step-by-Step Solution:

1. **Understanding Oxyhemoglobin Formation**:
- Oxyhemoglobin is formed when hemoglobin binds with oxygen. This reaction is represented as:
\[ \text{Hb} + \text{O}_2 \rightarrow \text{HbO}_2 \]
- This process primarily occurs in the lungs, specifically in the alveoli.

2. **Identifying Favorable Conditions**:
- The formation of oxyhemoglobin is influenced by several factors:
- **High pO2 (partial pressure of oxygen)**: A higher concentration of oxygen in the lungs promotes the binding of oxygen to hemoglobin.
- **Low pCO2 (partial pressure of carbon dioxide)**: Lower levels of carbon dioxide favor the formation of oxyhemoglobin.
- **Low H+ ion concentration (high pH)**: A lower concentration of hydrogen ions (which corresponds to a higher pH) is favorable for oxyhemoglobin formation.
- **Low temperature**: Cooler temperatures also favor the binding of oxygen to hemoglobin.

3. **Analyzing the Given Factors**:
- The question lists the following factors:
- High pO2
- Less H+ ion concentration
- Low pH
- Low temperature
- Among these, we need to identify which one is not favorable for the formation of oxyhemoglobin.

4. **Evaluating Each Factor**:
- **High pO2**: Favorable (promotes binding of oxygen).
- **Less H+ ion concentration**: Favorable (indicates high pH).
- **Low pH**: Not favorable (high H+ concentration indicates acidic conditions, which promote the release of oxygen from hemoglobin).
- **Low temperature**: Favorable (promotes binding of oxygen).

5. **Conclusion**:
- The factor that is not favorable for the formation of oxyhemoglobin is **low pH**.

### Final Answer:
The factor that is not favorable for the formation of oxyhemoglobin is **low pH**.

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