Arrange the following processes in the chronological order w.r.t cancer.
A. Metastasis
B. Activation of c - onc genes
C. Damage to neighboring cells .
D. Loss of control of cell cycle

Options

A. B-D-C-A
B. D-B-A-C
C. B-D-A-C
D. C-B-D-A

Answer

To arrange the processes in chronological order with respect to cancer, we need to understand the sequence of events that lead to cancer development. Here’s the step-by-step solution:

### Step-by-Step Solution:

1. **Activation of c-onc genes (B)**: The first step in the development of cancer is the activation of proto-oncogenes to oncogenes. This activation can be triggered by various factors such as chemicals, radiation, or viruses. Once these genes are activated, they promote uncontrolled cell division.

2. **Loss of control of the cell cycle (D)**: Following the activation of oncogenes, the next step is the loss of control over the cell cycle. This means that the normal regulatory mechanisms that control cell division are disrupted, leading to continuous and unregulated cell proliferation.

3. **Metastasis (A)**: As the cancerous cells continue to divide and form a tumor, they can invade surrounding tissues and spread to other parts of the body. This process is known as metastasis, where cancer cells break away from the original tumor and form new tumors in other organs.

4. **Damage to neighboring cells (C)**: Finally, as the cancer cells invade and proliferate, they cause damage to neighboring healthy cells. This damage can result in the destruction of normal tissue and further complications in the affected area.

### Chronological Order:
- B. Activation of c-onc genes
- D. Loss of control of cell cycle
- A. Metastasis
- C. Damage to neighboring cells

### Final Answer:
**B, D, A, C**