Mark the correct option.

Options

A. Turner's syndrome -45+ XO
B. Thalassemia- 44+YO
C. Klinefelters syndrome - 44+XXY
D. Phenylketonuria- 44+XYY

Answer

To solve the question regarding the correct genetic complement for the given genetic disorders, we will analyze each option step by step.

### Step 1: Understand the Genetic Disorders
We need to identify the genetic disorders mentioned in the options and their corresponding genetic complements. The two main categories of genetic disorders are Mendelian disorders and chromosomal disorders.

### Step 2: Analyze Turner's Syndrome
- **Turner's Syndrome**: This is a chromosomal disorder that occurs in females. The typical genetic complement for Turner's syndrome is 44 autosomes and one X chromosome (XO), which means the correct notation is 45 - XO.
- **Conclusion**: If the option states 45 - XO, it is correct. If it states anything else, it is incorrect.

### Step 3: Analyze Thalassemia
- **Thalassemia**: This is a Mendelian disorder caused by a defect in the hemoglobin gene. It does not involve a missing or extra chromosome but rather a mutation in a specific gene.
- **Conclusion**: Thalassemia cannot be the correct answer as it is not a chromosomal disorder.

### Step 4: Analyze Klinefelter Syndrome
- **Klinefelter Syndrome**: This is also a chromosomal disorder but occurs in males. The genetic complement for Klinefelter syndrome is 44 autosomes and two X chromosomes plus one Y chromosome (XXY).
- **Conclusion**: If the option states 44 - XXY, it is correct.

### Step 5: Analyze Phenylketonuria
- **Phenylketonuria (PKU)**: This is a Mendelian disorder that affects metabolism due to a defect in the gene responsible for breaking down phenylalanine. It does not involve chromosomal abnormalities.
- **Conclusion**: PKU cannot be the correct answer as it is not a chromosomal disorder.

### Final Conclusion
After analyzing all the options:
- Turner's syndrome has been given incorrectly if it states anything other than 45 - XO.
- Thalassemia and Phenylketonuria are not chromosomal disorders.
- Klinefelter syndrome is correctly identified as a chromosomal disorder with the complement 44 - XXY.

**The correct answer is option C: Klinefelter syndrome (44 - XXY).**

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