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Sickle-cell anaemia is caused by a subst...

Sickle-cell anaemia is caused by a substitution mutation. At this sixth position of haemoglobin, ………... due to this mutation

A

basic amino acid is replaced by acidic amino acid

B

acidic amino acid is replaced by basic amino acid

C

acidic amino acid is replaced by acidic amino acid

D

acidic amino acid is replaced by neutral amino acid

Text Solution

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The correct Answer is:
D
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Assertion :-Sickle-cell anaemia is caused by the substitution of glutamic acid by valine at the sixth position of the beta globin chain of the hemoglobin moecule. Reason :- It is due to the single base substitution at the sixth codon of the beta globin gene from GUG to GAG.