At the stage of generation of action potential, the axolemma is :

Options

A. Positive outside
B. Negative outside
C. Neither positive nor negative
D. Initially positive than negative

Answer

To solve the question regarding the state of the axolemma at the stage of action potential generation, we can follow these steps:

### Step-by-Step Solution:

1. **Understanding the Axolemma**:
- The axolemma is the membrane of the axon in a neuron. It plays a crucial role in the conduction of nerve impulses.

2. **Resting Potential**:
- Under resting conditions, the inside of the neuron is negatively charged (approximately -70 mV), while the outside is positively charged. This difference in charge is known as the resting potential.

3. **Action Potential Generation**:
- When an action potential is generated, there is a rapid change in membrane potential. This process begins at the axon hillock, where the action potential is initiated.

4. **Depolarization Phase**:
- During the generation of an action potential, the membrane undergoes depolarization. This means that the inside of the neuron becomes more positive as sodium ions (Na+) rush into the cell, while the outside becomes more negative.

5. **Final State of the Axolemma**:
- At the exact moment of action potential generation, the axolemma will have a positive charge outside and a negative charge inside, due to the influx of sodium ions.

6. **Choosing the Correct Option**:
- Based on the above understanding, the correct answer to the question, "At the stage of generation of action potential, the axolemma is:", is that it is **positive outside**.

### Conclusion:
The correct answer is that at the stage of generation of action potential, the axolemma is **positive outside**.

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