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A person suffering from severe chills an...

A person suffering from severe chills and recurring high fever for 3-4 days was diagnosed with malaria . The causative agent is responsible for the secretion of a toxic substance, which ruptures RBCs . This substance is called

A

Sporozoites

B

haematopoetin

C

haem- protease

D

haemozoin

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To solve the question regarding the toxic substance responsible for rupturing red blood cells (RBCs) in a person diagnosed with malaria, we can follow these steps: ### Step-by-Step Solution: 1. **Identify the Disease**: The person is suffering from malaria, which is characterized by severe chills and recurring high fever. 2. **Determine the Causative Agent**: The causative agent of malaria is a protozoan parasite known as *Plasmodium*. This parasite is transmitted to humans through the bite of infected female Anopheles mosquitoes. 3. **Understand the Mechanism of Infection**: Once the *Plasmodium* sporozoites enter the human bloodstream via the mosquito bite, they travel to the liver, where they multiply. After asexual reproduction in the liver, they are released back into the bloodstream. 4. **Identify the Effect on RBCs**: The released forms of *Plasmodium*, known as merozoites, invade red blood cells. Inside the RBCs, they undergo further development and multiplication. 5. **Recognize the Toxic Substance**: As the merozoites multiply, they eventually rupture the RBCs, leading to the release of a toxic substance. This substance is responsible for the symptoms of malaria, including fever and chills. 6. **Name the Toxic Substance**: The toxic substance released during the rupture of RBCs is called **hemozoin**. Hemozoin is a byproduct of the digestion of hemoglobin by the *Plasmodium* parasite and is responsible for the associated symptoms of malaria. ### Final Answer: The toxic substance responsible for rupturing RBCs in malaria is called **hemozoin**. ---
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