Cretinism is due to

Options

A. hyposecretion of thyroxine in adult
B. hypersecretion of thyroxine in childhood
C. hypersecretion of thyroid in adult
D. hyposecretion of thyroxine in childhood

Answer

### Step-by-Step Solution:

1. **Understanding Cretinism**:
- Cretinism is a condition that arises from a deficiency of thyroid hormones, particularly thyroxine (T4). It is characterized by severe physical and mental growth retardation.

2. **Identifying the Cause**:
- The primary cause of Cretinism is the hypo-secretion (underproduction) of thyroid hormones during childhood. This deficiency can lead to stunted growth and developmental issues.

3. **Analyzing the Options**:
- Let's evaluate the provided options:
- **Option 1**: Hypo secretion of Thyroxine in adult - Incorrect, as Cretinism primarily affects children.
- **Option 2**: Hypo secretion of Thyroxine in childhood - Correct, as this is the main cause of Cretinism.
- **Option 3**: Hypo secretion of thyroid in adult - Incorrect, similar reasoning as option 1.
- **Option 4**: Hypo secretion of Thyroxine in childhood - Correct, as this is the main cause of Cretinism.

4. **Conclusion**:
- The correct answer is that Cretinism is due to the hypo secretion of Thyroxine in childhood.

### Final Answer:
Cretinism is due to hypo secretion of Thyroxine in childhood.

---