Which one of the following conditions indicates Klinefeter's syndrome ?

Options

A. 44 + XXY
B. 44 + XO
C. 44 + XY
D. 44 + XX

Answer

To determine which condition indicates Klinefelter's syndrome, let's analyze the options provided step by step.

### Step 1: Understanding Klinefelter's Syndrome
Klinefelter's syndrome is a genetic condition that affects males. It is characterized by the presence of an extra X chromosome. Normally, males have one X and one Y chromosome (XY), but in Klinefelter's syndrome, they have an additional X chromosome, resulting in a chromosomal pattern of XXY.

### Step 2: Analyzing the Options
Now, let's look at the options given:

1. **Option 1: 44 + XXY**
- This indicates a total of 44 autosomes plus an additional XXY configuration, which is consistent with Klinefelter's syndrome.

2. **Option 2: 44 + XO**
- This configuration indicates Turner syndrome, which occurs in females who have only one X chromosome (XO).

3. **Option 3: 44 + XY**
- This is the normal male chromosomal configuration and does not indicate any syndrome.

4. **Option 4: 44 + XX**
- This configuration indicates a normal female chromosomal pattern and does not indicate Klinefelter's syndrome.

### Step 3: Conclusion
Based on the analysis, the correct answer is **Option 1: 44 + XXY**, which indicates Klinefelter's syndrome.

### Final Answer:
**The condition that indicates Klinefelter's syndrome is 44 + XXY.**

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