All are correct with respect to the Human Genome project , except

Options

A. Its goal was to determine the sequence of the 3 billion chemical base pairs that make up human DNA
B. Caenorhabditis elegans and Arabidopsis are the non-human model organisms, that have been sequence
C. The sequence of chromosome -1 was completely only in May 2006 , this was the last of the 24 human chromosomes to be sequenced
D. 14 million locations are identified in humans with single base DNA differences

Answer

To solve the question regarding the Human Genome Project, we need to evaluate each of the provided options and determine which one is incorrect.

### Step-by-Step Solution:

1. **Understand the Human Genome Project (HGP)**:
- The HGP was a significant scientific endeavor aimed at mapping and understanding all the genes of the human species. It involved sequencing the entire human genome, which consists of approximately 3 billion base pairs.

2. **Evaluate Option A**:
- **Statement**: "Its goal was to determine the sequence of 3 billion chemical base pairs that make up human DNA."
- **Analysis**: This statement is correct as the primary goal of the HGP was indeed to sequence the 3 billion base pairs of human DNA.

3. **Evaluate Option B**:
- **Statement**: "C. elegans and Arabidopsis are the non-human model organisms that have been sequenced."
- **Analysis**: This statement is also correct. C. elegans (a nematode) and Arabidopsis (a plant) were sequenced as part of the HGP to help understand human genetics.

4. **Evaluate Option C**:
- **Statement**: "Sequence of chromosome 1 was completely sequenced only in May 2006. This was the last of 24 human chromosomes to be sequenced."
- **Analysis**: This statement is correct. Chromosome 1 was indeed the last of the 24 chromosomes to be fully sequenced, with the completion occurring in May 2006.

5. **Evaluate Option D**:
- **Statement**: "14 million locations are identified in humans with single base DNA differences."
- **Analysis**: This statement is incorrect. The actual number of identified locations with single base differences (single nucleotide polymorphisms or SNPs) is approximately 1.4 million, not 14 million.

6. **Conclusion**:
- The incorrect statement regarding the Human Genome Project is **Option D**.

### Final Answer:
The answer is **Option D**: "14 million locations are identified in humans with single base DNA differences."

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