In which of these disease's does the patient doesn't have the same number of chromosomes as the rest ?

Options

A. Down's syndrome
B. Edward's syndrome
C. Turner's syndrome
D. Klinefelter's syndrome

Answer

To solve the question regarding which disease results in a patient having a different number of chromosomes compared to the normal count, we will analyze each option step by step.

### Step-by-Step Solution:

1. **Understanding Chromosome Count**:
- A normal human cell typically has 46 chromosomes, arranged in 23 pairs.

2. **Analyzing Down Syndrome**:
- Down syndrome is caused by the trisomy of chromosome 21.
- This means there is an extra chromosome (one additional chromosome) at the 21st position.
- Total chromosome count = 46 (normal) + 1 (extra) = 47 chromosomes.

3. **Analyzing Edwards Syndrome**:
- Edwards syndrome is caused by the trisomy of chromosome 18.
- Similar to Down syndrome, this results in an extra chromosome at the 18th position.
- Total chromosome count = 46 (normal) + 1 (extra) = 47 chromosomes.

4. **Analyzing Turner Syndrome**:
- Turner syndrome occurs when there is a missing X chromosome in females.
- Normally, females have two X chromosomes (XX), but in Turner syndrome, one X is absent.
- Total chromosome count = 44 (autosomes) + 1 (X) = 45 chromosomes.

5. **Analyzing Klinefelter Syndrome**:
- Klinefelter syndrome occurs in males who have an extra X chromosome.
- Normally, males have one X and one Y chromosome (XY), but in Klinefelter syndrome, there is an additional X chromosome.
- Total chromosome count = 44 (autosomes) + 2 (XXY) = 47 chromosomes.

6. **Conclusion**:
- Among the options:
- Down syndrome: 47 chromosomes
- Edwards syndrome: 47 chromosomes
- Turner syndrome: 45 chromosomes
- Klinefelter syndrome: 47 chromosomes
- The only condition where the patient does not have the same number of chromosomes as the normal count is Turner syndrome, which has 45 chromosomes.

### Final Answer:
**Turner syndrome (Option C) is the disease where the patient does not have the same number of chromosomes as the rest.**