Sequence annotation in human genome project refers to

Options

A. identification of only those genes that are expressed as RNA
B. correlating , sequence of of nucleotides already known for an organism, to their functions
C. Selection of base sequence not involved in Protein synthesis
D. Both (A) and (B)

Answer

To solve the question about sequence annotation in the Human Genome Project, we will analyze the options provided and determine the correct answer step by step.

### Step 1: Understanding Sequence Annotation
Sequence annotation refers to the process of identifying and labeling the various functional elements within a genome. This includes genes, regulatory elements, and other important sequences.

**Hint:** Think about what sequence annotation aims to achieve in the context of a genome.

### Step 2: Analyzing the Options
- **Option A:** Identification of only those genes that are expressed as RNA.
- This option focuses solely on expressed genes, which is a part of sequence annotation but not the entirety of it.

- **Option B:** Correlating the sequence of nucleotides already known for an organism to their function.
- This option describes a broader aspect of sequence annotation, where known sequences are linked to their functions, which is a key part of the annotation process.

- **Option C:** Selection of base sequences not involved in protein synthesis.
- This option refers to non-coding regions, which are also part of the genome but do not encompass the full scope of sequence annotation.

- **Option D:** Both A and B.
- This option suggests that both identifying expressed genes and correlating sequences to functions are part of sequence annotation.

### Step 3: Evaluating the Best Option
While options A and C describe specific aspects of the genome, option B captures the essence of sequence annotation by emphasizing the correlation of known sequences to their functions. Therefore, option D, which includes A, is not entirely correct since it does not encompass the broader definition provided by option B.

### Conclusion
After evaluating all options, the correct answer is **Option B: correlating the sequence of nucleotides already known for an organism to their function**.

**Final Answer:** Option B

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