Which of the following is incorrect regarding the erythroblastosis foetalis condition in a pregnant woman ?

Options

A. It is a special case arises due to Rh incompatibility or mismatching
B. Destruction of Rh(+ve) foetal RBC inside Rh(-ve) pregnant mother
C. Specific antibodies against Rh antigens are formed inside foetal blood
D. It can be prevented by injecting anti-Rh antibodies to the mother

Answer

To solve the question regarding erythroblastosis foetalis and identify the incorrect statement, we can follow these steps:

### Step-by-Step Solution:

1. **Understand Erythroblastosis Foetalis**:
- Erythroblastosis foetalis is a condition that occurs when an Rh-negative mother carries an Rh-positive fetus. This incompatibility can lead to serious complications for the fetus.

**Hint**: Remember that Rh factor refers to a specific protein on red blood cells, and incompatibility arises when the mother lacks this protein while the fetus has it.

2. **Mechanism of the Condition**:
- During delivery, some fetal blood may enter the mother’s circulation. The mother’s immune system recognizes the Rh-positive fetal red blood cells as foreign and produces antibodies against them.

**Hint**: Focus on the immune response of the mother and how it reacts to the fetal blood cells.

3. **Consequences in Subsequent Pregnancies**:
- In a subsequent pregnancy with another Rh-positive fetus, the mother’s pre-formed antibodies can cross the placenta and attack the fetal red blood cells, leading to their destruction.

**Hint**: Think about how the first pregnancy affects the mother’s immune system for future pregnancies.

4. **Evaluate the Statements**:
- **Option 1**: "It is a special case arising due to the Rh incompatibility."
- This statement is correct.
- **Option 2**: "Destruction of Rh-positive fetal RBC inside the Rh-negative pregnant mother."
- This statement is also correct.
- **Option 3**: "Specific antibodies against this Rh antigen are formed inside the fetal blood."
- This statement is incorrect because the antibodies are formed in the mother’s blood, not the fetal blood.
- **Option 4**: "It can be prevented by injecting the anti-Rh antibody to the mother."
- This statement is correct as administering anti-Rh immunoglobulin can prevent the mother from forming antibodies.

5. **Identify the Incorrect Statement**:
- The incorrect statement is **Option 3**, as it misstates where the antibodies are formed.

**Hint**: Look for the statement that contradicts the established understanding of where the immune response occurs.

### Final Answer:
The incorrect statement regarding erythroblastosis foetalis is **Option 3**: "Specific antibodies against this Rh antigen are formed inside the fetal blood."