Generation of second messengers is not possible in which of the given set of hormones ?

Options

A. Epinephrine, insulin glucagon
B. Estrogen, cortisol, thyroxine
C. FSH, LH, oxytocin
D. Estradiol, oxytocin, FSH

Answer

To solve the question regarding which set of hormones does not generate second messengers, we can follow these steps:

### Step-by-Step Solution:

1. **Understand Hormone Types**:
- Hormones can be classified based on their chemical nature into different categories: peptide hormones, steroid hormones, iodothyronines, and amino acid derivatives.

2. **Identify Receptor Types**:
- Hormones bind to receptors on target cells, which can be either membrane-bound receptors or intracellular receptors.
- Membrane-bound receptors typically lead to the production of second messengers (e.g., cAMP, IP3).
- Intracellular receptors do not produce second messengers.

3. **Analyze the Given Hormones**:
- **Option 1**: Epinephrine, Insulin, and Glucagon
- All are peptide hormones and bind to membrane receptors, thus they generate second messengers.
- **Option 2**: Estrogen, Cortisol, and Thyroxine
- Estrogen and Cortisol are steroid hormones, and Thyroxine is an iodothyronine. All three bind to intracellular receptors and do not generate second messengers.
- **Option 3**: FSH, LH, and Oxytocin
- FSH and LH are peptide hormones, and Oxytocin is also a peptide hormone. Therefore, they generate second messengers.
- **Option 4**: Not provided in the transcript, but we can conclude based on the analysis.

4. **Conclusion**:
- The correct answer is **Option 2: Estrogen, Cortisol, and Thyroxine**, as these hormones do not generate second messengers due to their binding to intracellular receptors.

### Final Answer:
The generation of second messengers is not possible in the set of hormones: **Estrogen, Cortisol, and Thyroxine**.