Read the following statements and choose...

Read the following statements and choose the correct option
I. Failure of segregation of chromatids during cell division results in aneuploidy
(II) Chromosomal disorders are mainly determined buy alteration or mutation in a single gene
(III) Thalassemia and cystic fibrosis are Mendelian disorders
(IV) Sickle cell anemia is an X- linked trait ltbvrgt (V) Haemophilia is an autosome linked recessive disease

A and C are correct

C and D are correct

B and D are correct

A, C and D are correct

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AI Generated Solution

The correct Answer is:

To solve the question, we need to analyze each statement provided and determine which ones are correct. ### Step-by-Step Solution: 1. **Statement I: Failure of segregation of chromatids during cell division results in aneuploidy.** - **Analysis**: This statement is true. Aneuploidy refers to an abnormal number of chromosomes due to improper segregation during cell division. If chromatids do not separate correctly, it can lead to cells with extra or missing chromosomes. - **Conclusion**: **True** 2. **Statement II: Chromosomal disorders are mainly determined by alteration or mutation in a single gene.** - **Analysis**: This statement is false. Chromosomal disorders are typically caused by structural abnormalities or numerical changes in chromosomes, not just mutations in a single gene. They can involve multiple genes and complex interactions. - **Conclusion**: **False** 3. **Statement III: Thalassemia and cystic fibrosis are Mendelian disorders.** - **Analysis**: This statement is true. Both thalassemia and cystic fibrosis are inherited in a Mendelian manner, specifically as autosomal recessive disorders. They are caused by mutations in single genes. - **Conclusion**: **True** 4. **Statement IV: Sickle cell anemia is an X-linked trait.** - **Analysis**: This statement is false. Sickle cell anemia is an autosomal recessive disorder, not X-linked. It is caused by a mutation in the HBB gene on chromosome 11. - **Conclusion**: **False** 5. **Statement V: Haemophilia is an autosome-linked recessive disease.** - **Analysis**: This statement is false. Haemophilia is an X-linked recessive disorder, meaning the gene responsible for it is located on the X chromosome. - **Conclusion**: **False** ### Summary of Findings: - Statement I: True - Statement II: False - Statement III: True - Statement IV: False - Statement V: False ### Correct Options: The correct statements are I and III. Therefore, the correct answer is that statements I and III are correct. ### Final Answer: **The correct option is that statements I and III are correct.** ---

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