Which of the following is not related to follicular phase of the menstrual cycle?

Options

A. Development of Graafian follicle
B. Regeneration of lost endometerium
C. Release of estrogen hormone
D. Endometrium becomes secretory

Answer

To solve the question "Which of the following is not related to the follicular phase of the menstrual cycle?", we will analyze each option provided in the context of the menstrual cycle phases.

### Step-by-Step Solution:

1. **Understand the Phases of the Menstrual Cycle**:
The menstrual cycle consists of three main phases:
- Follicular Phase
- Ovulatory Phase
- Luteal Phase (also known as the Secretory Phase)

2. **Identify the Follicular Phase**:
The follicular phase starts on the first day of menstruation and lasts until ovulation. It is characterized by the development of ovarian follicles and an increase in estrogen levels.

3. **Analyze Each Option**:
- **Option 1: Development of the Graafian Follicle**:
This is indeed related to the follicular phase as the phase involves the maturation of ovarian follicles, leading to the development of the Graafian follicle.

- **Option 2: Regeneration of the Lost Endometrium**:
This process occurs after menstruation during the follicular phase as the endometrium rebuilds itself in preparation for a potential pregnancy.

- **Option 3: Release of the Estrogen Hormone**:
During the follicular phase, estrogen levels rise due to the development of follicles, making this option relevant to the follicular phase.

- **Option 4: Endometrium Becomes Secretory**:
This is not related to the follicular phase. The endometrium becomes secretory during the luteal phase, preparing for possible implantation of an embryo.

4. **Conclusion**:
The option that is not related to the follicular phase of the menstrual cycle is **Option 4: Endometrium Becomes Secretory**.

### Final Answer:
**Option 4: Endometrium Becomes Secretory** is not related to the follicular phase of the menstrual cycle.

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