Choose the wrong statement from the following.

Options

A. Failure of segragation of chromatides during cell divisin result in aneuploidy
B. Additional copy of 'X' chromosome in male result in Klinefelter's syndrome.
C. Closely located genes in a chromosome always assort independently resulting in recombinations
D. Failure of cytokinesis after DNA replication results in polyploidy

Answer

To solve the question of identifying the wrong statement among the given options, we will analyze each statement step by step.

### Step 1: Analyze the First Statement
**Statement:** Failure of segregation of chromatids during cell division results in aneuploidy.

**Analysis:** This statement is correct. When chromatids fail to segregate properly during cell division, it can lead to aneuploidy, which is a condition characterized by an abnormal number of chromosomes (either too many or too few). This can result in various genetic disorders.

**Hint:** Remember that aneuploidy is often caused by errors in chromosome segregation during meiosis or mitosis.

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### Step 2: Analyze the Second Statement
**Statement:** An additional copy of the X chromosome in males results in Klinefelter syndrome.

**Analysis:** This statement is also correct. Klinefelter syndrome occurs when a male has one or more extra X chromosomes, typically resulting in a 47,XXY karyotype. It is a genetic condition that can affect physical and cognitive development.

**Hint:** Klinefelter syndrome is specifically associated with males having an extra X chromosome.

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### Step 3: Analyze the Third Statement
**Statement:** Closely located genes on a chromosome always assort independently, resulting in recombination.

**Analysis:** This statement is incorrect. Genes that are located close together on the same chromosome tend to be inherited together and do not assort independently. This phenomenon is known as genetic linkage. Recombination can occur, but it is less likely for genes that are closely linked compared to those that are far apart.

**Hint:** Recall the concept of linked genes and how they behave differently from independently assorting genes.

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### Step 4: Analyze the Fourth Statement
**Statement:** Failure of cytokinesis after DNA replication results in polyploidy.

**Analysis:** This statement is correct. Polyploidy is a condition where a cell has more than two complete sets of chromosomes, which can occur if cytokinesis fails after DNA replication, leading to cells with multiple nuclei or increased genomic content.

**Hint:** Polyploidy is often seen in plants and can result from errors in cell division.

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### Conclusion
After analyzing all the statements, the wrong statement is:

**Answer:** The third statement is incorrect: "Closely located genes in a chromosome always assort independently resulting in recombination."

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