The hormone which suppresses the immune system is produce by

Options

A. zona fasciculata of adrenal cortex
B. zona glomerulosa of adrenal cortex
C. zona reticular's of adrenal cortex
D. Both (A) and (C )

Answer

To solve the question regarding which hormone suppresses the immune system and where it is produced, we can follow these steps:

### Step 1: Identify the Hormones Produced by the Adrenal Cortex
The adrenal cortex is divided into three layers:
- Zona Glomerulosa
- Zona Fasciculata
- Zona Reticularis

### Step 2: Determine the Hormones Secreted by Each Layer
1. **Zona Glomerulosa**: This layer primarily secretes **aldosterone**, which is involved in regulating electrolyte balance and does not play a significant role in immune suppression.

2. **Zona Fasciculata**: This layer secretes **cortisol**, which is known to have potent anti-inflammatory properties and plays a significant role in suppressing the immune system.

3. **Zona Reticularis**: This layer secretes **androgens**, which are sex hormones. Recent studies suggest that androgens may also have immunosuppressive effects, although this is less commonly emphasized.

### Step 3: Analyze the Options Given in the Question
The question provides the following options:
- A) Zona Fasciculata of adrenal cortex
- B) Zona Glomerulosa of the adrenal cortex
- C) Zona Reticularis of the adrenal cortex
- D) Both A and C

From our analysis:
- **A (Zona Fasciculata)** is correct because it produces cortisol, which suppresses the immune system.
- **B (Zona Glomerulosa)** is incorrect because it produces aldosterone, which does not suppress the immune system.
- **C (Zona Reticularis)** is partially correct as androgens may have immunosuppressive effects.
- **D (Both A and C)** is also correct because both cortisol and androgens can suppress the immune response.

### Step 4: Conclusion
The most accurate answer to the question is **D) Both A and C**, as both the zona fasciculata (cortisol) and zona reticularis (androgens) can suppress the immune system.

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