Which one of the following is not the reason for very high load of bilirubin?

Options

A. Excessive destruction red blood corpuscles
B. Impaired uptake of bilirubin by liver cells
C. Ingestion of iron supplements
D. Insoluble bilirubin in the intestine is reabsorbed by the blood

Answer

To determine which option is not a reason for a very high load of bilirubin, we will analyze each option provided in the question.

### Step-by-Step Solution:

1. **Understanding Bilirubin**:
- Bilirubin is a yellow pigment produced during the breakdown of red blood cells (RBCs). It is primarily processed in the liver.
- When RBCs are broken down, hemoglobin is released, which is then converted into bilirubin.

2. **Identifying the Causes of High Bilirubin Levels**:
- High bilirubin levels can occur due to various reasons, including:
- **Excessive destruction of red blood corpuscles**: This leads to an increased production of bilirubin as more RBCs are broken down.
- **Impaired uptake of bilirubin by liver cells**: If the liver cannot take up bilirubin effectively, it accumulates in the blood.
- **Insoluble bilirubin reabsorbed by the blood**: If bilirubin is not excreted properly, it can be reabsorbed, leading to higher levels in the bloodstream.

3. **Analyzing the Options**:
- **Option 1: Excessive destruction of red blood corpuscles**: This would increase bilirubin levels, so it is a reason for high bilirubin.
- **Option 2: Impaired uptake of bilirubin by liver cells**: This would also lead to increased bilirubin levels, making it a reason for high bilirubin.
- **Option 3: Ingestion of iron supplement**: Iron supplements generally increase the production of RBCs. More RBCs could mean less breakdown and, therefore, less bilirubin production. This option does not contribute to high bilirubin levels.
- **Option 4: Insoluble bilirubin in the intestine is reabsorbed by the blood**: This would lead to increased bilirubin levels, so it is a reason for high bilirubin.

4. **Conclusion**:
- The option that is **not** a reason for a very high load of bilirubin is **Option 3: Ingestion of iron supplement**.

### Final Answer:
**Option 3: Ingestion of iron supplement** is not a reason for very high load of bilirubin.