Which of th following does not favour the large quantities of dilute urine ?

Options

A. Renin
B. Atrial Natriuretic Factor
C. Alcohol
D. Caffeine

Answer

To solve the question "Which of the following does not favour the large quantities of dilute urine?" we will analyze each option provided: renin, atrial natriuretic factor (ANF), alcohol, and caffeine.

### Step-by-Step Solution:

1. **Understanding the Question**: We need to identify which of the options does not promote the production of large quantities of dilute urine.

2. **Analyzing Renin**:
- Renin is released by the juxtaglomerular apparatus (JGA) in response to low blood pressure.
- Its primary function is to promote the reabsorption of sodium (Na+) and water in the kidneys.
- Increased reabsorption of water leads to less dilute urine, as more water is retained in the body.
- **Conclusion**: Renin does not favor the production of large quantities of dilute urine.

3. **Analyzing Atrial Natriuretic Factor (ANF)**:
- ANF is secreted by the heart and works to reduce blood volume and pressure.
- It inhibits the reabsorption of sodium and water in the kidneys, promoting their excretion.
- This action favors the production of dilute urine.
- **Conclusion**: ANF favors the production of dilute urine.

4. **Analyzing Alcohol**:
- Alcohol inhibits the secretion of antidiuretic hormone (ADH).
- ADH normally promotes water reabsorption in the kidneys.
- When alcohol suppresses ADH, less water is reabsorbed, leading to increased urine volume and more dilute urine.
- **Conclusion**: Alcohol favors the production of dilute urine.

5. **Analyzing Caffeine**:
- Caffeine acts as a diuretic, similar to alcohol.
- It can inhibit the reabsorption of water, leading to increased urine output.
- This also results in the production of more dilute urine.
- **Conclusion**: Caffeine favors the production of dilute urine.

### Final Answer:
Based on the analysis, the option that does not favor the large quantities of dilute urine is **Renin**.