Osteoporosis, an age-related disease of skeletal system, may occur due to :

Options

A. Decreased level of estrogen
B. Accumulation of uric acid leading to inflammation joints.
C. Immune disorder affecting neuromuscular junction leading to fatigue.
D. High concentration of `Ca^(++) and Na^(+)`

Answer

**Step-by-Step Solution:**

1. **Understanding Osteoporosis**: Osteoporosis is an age-related disease that affects the skeletal system, leading to weakened bones and an increased risk of fractures.

2. **Identifying Causes**: The question asks for the cause of osteoporosis. We need to analyze the provided options to determine which one is correct.

3. **Evaluating the Options**:
- **Option A**: "The level of Osteogenes decreases." This refers to the decrease in estrogen levels, which is known to affect bone density. Estrogen plays a crucial role in maintaining bone health, and its decrease can lead to osteoporosis.
- **Option B**: "Uric acid accumulates, due to which inflammation occurs in the joints." This is more related to gout and does not directly cause osteoporosis.
- **Option C**: "It is an immune disorder, which affects many neuromuscular joints, which causes fatigue." This does not specifically relate to osteoporosis.
- **Option D**: "The concentration of calcium and sodium ions is very high." While calcium is important for bone health, high levels do not cause osteoporosis; rather, low calcium levels contribute to the disease.

4. **Conclusion**: Based on the analysis, the correct answer is **Option A**: The level of Osteogenes (estrogen) decreases, leading to osteoporosis.