Sickle cell anemia is...

Sickle cell anemia is

caused by a change in a single base pair of DNA

characterized by elongated sickle like RBCs with a nucleus

an autosomal linked dominant trait

caused by substitution of valine by glutamic acid in the beta globin chain of haemoglobin

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Read the following statements and choose the correct option. (i) In phenylketonuria the affected person does not secrete the enzyme to convert phenylalanine to tyrosine. (ii) The possibility of a male becoming haemophilic is extremely rare. (iii) Sickle cell anemia is caused by the substitution of glutamic acid by valine at the fifth position of beta chain of haemoglobin molecule. (iv) Myotonic dystrophy is an autosomal dominant trait.

The gene of sickle cell anaemia is inherited by

Sickle cell anaemia is due to substitution/transversion (point mutation) in which

[A]: Genetic disorder, sickle cell anaemia is common in new born babies· [R]: It is caused by heterozygosity for allble Hbc, producing a single ammo acid substitu tion in the a-chain of the Haemoglobin deter- mined by allele Hb^A

Sickle-cell anaemia is caused due to the substitution of :

[A]: Sickle-cell anaemia is a genetically de- termined disorder affecting many new born babies. [R]: It is caused by heterozygosity for allele Hb^c , producing a single amino acid substitu- tion in the a-chain of the normal haemoglo- bin molecule determined by allele Hb^A .

Pick out the correct statement (I) Haemophilia is a sex-linked recessive disease (II) Down's syndrome is due to aneuploidy (III) Phenylketonuria is an autosomal recessive gene disorder lt brgt (IV) Sickle-cell anaemia is an X-linked recessive gene disorder

Thalassemia and sickle cell anemia are caused due to a problem in globin molecule synthesis. Select the correct statement

The shape of RBCs of sickle cell anaemia patients change to elongated sickle like structure. Give reason.

TRUEMAN BIOLOGY-PRINCIPLES OF INHERITANCE AND VARIATIONS -MCQs

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