Explain the hormonal regulation of the process of spermatogenesis in humans.

Explanation

Spermatogenesis starts at the age of puberty due to significant increase in the secretion of gonadotropin releasing hormone (GnRH) from the hypothalamus. GnRH acts at the anterior pituitary gland and stimulates secretion of two gonatodropins - luteinizing hormone (LH) and follicle stimulating hormone (FSH). LH acts at the Leydig cells and stimulates secretion of testosterone - a principle androgen. Testosterone is essential for sperm formation. Androgen in turn stimulates the processes spermatogenesis. FSH acts on Sertoli cells and stimulates secretion of some factors (like ABP-androgen binding protein) which help in the process of spermiogenesis. They bind to testosterone and concentrate testosterone in seminiferous tubules.