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(a) State the central dogma in molecular...

(a) State the central dogma in molecular biology. Who proposed it? Is it universally applicable? Explain.
(b) List any four properties of a molecule to be able to act as a genetic material

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(a) Francis Crick proposed the 'central dogma' in molecular biology which states that the genetic information flows from

In some viruses, the flow of information is in reverse direction, that is from RNA to DNA
(b) Properties in a molecule to act as a genetic material: It should be able to generate its replica. It should chemically and structurally be stable It should provide scope for slow changes (mutation) that are required for evolution It should be able to express itself in the form of Mendelian characters.
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Study the following carefully and explain why mutation (A) did not cause any sickle cell anemia in spite of change in the molecular structure of the gene which codes for Haemoglobin, when as a similar mutation (B) did. (The question is based on properties of the genetic code. c= codon, a = amino acid, Hb = Haemoglobin) Codons for Hb: C_1 - C_2 -C_3 -C_4 - C_5 -G AA -GAA- C_8 ... Amino acids in Hb : a_1-a_2-a_3-a_4-a_5 - Glutamic acid- Glutamic acid - a_8 ...... (Normal Haemoglobin ) Mutation (A) : C_1 -C_2 - C_3 -C_4 -C_5-GAG-"GAA"-C_8...... a_1-a_2 - a_3-a_4-a_5 -Glutamic acid -Glutamic acid - a_8 .... (Normal Haemoglobin ) Mutation (B) : C_1 -C_2 - C_3 -C_4 -C_5-GAG-"GAA"-C_8...... a_1-a_2 - a_3-a_4-a_5 -Valine-Glutamic acid - a_8 .... (Sickle cell Haemoglobin )

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