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[A]: Genetic disorder, sickle cell anaem...

[A]: Genetic disorder, sickle cell anaemia is common in new born babies·
[R]: It is caused by heterozygosity for allele Hbc, producing a single amino acid substitution in the a-chain of the Haemoglobin determined by allele `Hb^A`

A

If both A and R are true and R is the correct explanation of A

B

If both A and R are true but R is not the correct explanation of A

C

If A is true and R is false

D

If both A and R are false

Text Solution

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The correct Answer is:
C
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[A]: Sickle-cell anaemia is a genetically de- termined disorder affecting many new born babies. [R]: It is caused by heterozygosity for allele Hb^c , producing a single amino acid substitu- tion in the a-chain of the normal haemoglo- bin molecule determined by allele Hb^A .

In sickle cell anaemia, the sequence of amino acid from first to seventh position of beta -chain of haemoglobin S (HbS) is

Sickle-cell anemia is caused due to the substitution of : 1. Valine by glutamic acid at sixth position of alpha chain of heamoglobin 2. Valine by glutamic acid at sixth position of beta chain of haemoglobin 3. glutamic acid by valine at sixth position of alpha chain of haemoglobin 4. glutamic acid by valine at sixth position of beta chain of haemoglobin

Study the following carefully and explain why mutation (A) did not cause any sickle cell anemia in spite of change in the molecular structure of the gene which codes for Haemoglobin, when as a similar mutation (B) did. (The question is based on properties of the genetic code. c= codon, a = amino acid, Hb = Haemoglobin) Codons for Hb: C_1 - C_2 -C_3 -C_4 - C_5 -G AA -GAA- C_8 ... Amino acids in Hb : a_1-a_2-a_3-a_4-a_5 - Glutamic acid- Glutamic acid - a_8 ...... (Normal Haemoglobin ) Mutation (A) : C_1 -C_2 - C_3 -C_4 -C_5-GAG-"GAA"-C_8...... a_1-a_2 - a_3-a_4-a_5 -Glutamic acid -Glutamic acid - a_8 .... (Normal Haemoglobin ) Mutation (B) : C_1 -C_2 - C_3 -C_4 -C_5-GAG-"GAA"-C_8...... a_1-a_2 - a_3-a_4-a_5 -Valine-Glutamic acid - a_8 .... (Sickle cell Haemoglobin )

TRUEMAN BIOLOGY-Genetics-ASSERTION AND REASON
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  12. [A]: A gene affecting the expression of another nonallelic gene is cal...

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  13. [A]: The sex linked genes are passed on to the grandson through the da...

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  14. Assertion : Mutations are necessary for the survival to the species. ...

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  16. [A]: Neurospora is an ideal genetic material for research. [R]: Bec...

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  17. [A]: Heterosis is superiority of F1 hybrid over its two genetically d...

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  18. [A]: Mendelian recombinations are due to crossing over. [R]: Crossi...

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  19. [A]: Genes confined to differential region of homologous chromosomes a...

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  20. [A]: Chromosomes appear longer during telophase. [R]: The term chro...

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