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What is Blood testis barrier ?...

What is Blood testis barrier ?

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The Blood Testis Barrier (BTB) is one of the tightest blood tissue barriers in mammalian body. It divides the seminiferous epithelium into the basal and apical compartments. Meiosis-I and II, spermiogenesis and spermiation all occur in a specialised microenvironment behind BTB in the apical compartment but spermatogonial renewal and differentiation and cell cycle progression up to preleptotene spermatocyte stage takes place outside of the BTB in the basal compartment. BTB is different from most other tissue barriers in that it is not only comprised of tight junctions. Desmosomes, gap junctions and ectoplasmic specialisations also occur in it.
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