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Both antacids and antiallergic drugs are...

Both antacids and antiallergic drugs are antihistamines but they cannot replace each other. Why?

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If the site of function of a drug is different, there is no interference in action of the two. Drugs designed to cure some ailment in one organ of the body that do not produce any effect to the other because they work on different receptors. For instance, secretion of histamine causes allergy. It also causes acidity due to release of HCI in the stomach. Since, antiallergic and antacid drugs work on different receptors, thus antihistamines remove allergy while antacid remove acidity.
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