Select the autosomal dominant, autosomal recessive, X-sex linked recessive and Y-sex linked recessive disorders respectively.

Options

A. Myotonic dystrophy, SCA, Haemophilia and hypertrichosis
B. Huntington's chorea, PKU (phenylketonuria), colour-blindness and webbed toes
C. Polydactyly, Thalassemia G-6-P dehydrogenase deficiency and long hairs on pinna
D. All of the above

Answer

D

Explanation

LAutosomal dominant disorders
e.g.: 1. Myotonic dystrophy
2. Huntington.s chorea (chromosome 4)
3. Phenylthiocarbamide (PTC) testing
4. Polydactyly in man.
II. Autosomal recessive disorders
e.g.: 1. SCA
2. PKU (Phenylketonuria)
3. Alkaptonuria
4. Albinism
5. Gaucher.s disease (chromosome-1)
6. Tay Sach.s disease
7. Thalassaemia
8. Cystic fibrosis (chromosome-7)
9. Galactosemia
III. Sex-linked (X) recessive disorders
e.g.: 1. Haemophilia/ Bleeder.s disease
2. Colour-blindness
3. Congenital night blindness
4. DMD (Duchenne .s muscular dystrophy)
5. G-6-P dehydrogenase deficiency
IV. Y Sex-linked disorder
e.g.: Hypertrichosis (long hairs present on pinna of ear) and webbed toes.