Assertion : Aspirin can cause ulcer in s...

Assertion `:` Aspirin can cause ulcer in stomach when taken empty stomach.
Reason `:` Aspirin gets hydrolysed to salicyclic acid in stomach where `pH` is 2.

If both assertion and Reason are true and the Reason is the correct explanation of the assertion.

If both assertion and Reason are true but the reason is not the correct explanation of the assertion

If assertion is true but reason is false

If both assertion and reason are false.

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The correct Answer is:

**Step-by-Step Text Solution:** 1. **Understanding the Assertion**: The assertion states that "Aspirin can cause ulcer in stomach when taken empty stomach." This is true because aspirin (acetylsalicylic acid) can irritate the stomach lining, especially when taken without food. 2. **Understanding the Reason**: The reason states that "Aspirin gets hydrolyzed to salicylic acid in stomach where pH is 2." This is also true. In the acidic environment of the stomach (pH around 2), aspirin undergoes hydrolysis, breaking down into salicylic acid and acetic acid. 3. **Chemical Structure of Aspirin**: Aspirin is chemically known as acetylsalicylic acid. Its structure includes an acetyl group (–COCH3) and a salicylic acid moiety. The presence of the ester bond (–COO–) is crucial for its hydrolysis. 4. **Hydrolysis Reaction**: When aspirin is ingested, especially on an empty stomach, the acidic conditions promote hydrolysis. The reaction can be represented as: \[ \text{Aspirin} \xrightarrow{\text{H}_2\text{O}} \text{Salicylic Acid} + \text{Acetic Acid} \] This hydrolysis leads to the formation of salicylic acid, which can irritate the stomach lining and potentially cause ulcers. 5. **Conclusion**: Both the assertion and the reason are true. The reason provided correctly explains why the assertion is valid. Therefore, the correct answer is that both the assertion and reason are true, and the reason is the correct explanation of the assertion. **Final Answer**: Both assertion and reason are true, and the reason is the correct explanation of the assertion. ---

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Assertion `:` Aspirin can cause ulcer in stomach when taken empty stomach. Reason `:` Aspirin gets hydrolysed to salicyclic acid in stomach where `pH` is 2.

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Assertion `:` Aspirin can cause ulcer in stomach when taken empty stomach.
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