Administration of which of the following compound increases clotting time

Options

A. dicumarol
B. aspirin
C. heparin
D. all of the above

Explanation

To solve the question "Administration of which of the following compound increases clotting time?" we need to analyze each of the given options and determine their effects on blood clotting.

### Step-by-Step Solution:

1. **Understanding Clotting Time**:
- Clotting time refers to the duration it takes for blood to form a clot. Compounds that increase clotting time are known as anticoagulants. These substances prevent or inhibit the clotting process.

2. **Analyzing the Options**:
- **Option A: Dicoumarol**:
- Dicoumarol is a naturally occurring anticoagulant that works by inhibiting vitamin K. Vitamin K is essential for the synthesis of certain clotting factors. By depleting vitamin K, dicoumarol effectively increases clotting time.

- **Option B: Aspirin**:
- Aspirin is a non-steroidal anti-inflammatory drug (NSAID) that inhibits platelet aggregation. By preventing platelets from clumping together, aspirin also increases clotting time, making it an anticoagulant.

- **Option C: Heparin**:
- Heparin is a widely used anticoagulant that works by inhibiting various factors in the clotting cascade. It slows down the clotting process, thereby increasing clotting time.

3. **Conclusion**:
- Since all three compounds—dicoumarol, aspirin, and heparin—are known to increase clotting time, the correct answer is:
- **Option D: All of the above**.

### Final Answer:
**All of the above (Dicoumarol, Aspirin, Heparin)** increase clotting time.

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