Malaria fever coincides with liberation of

Options

A. Cryptomerozoites
B. Metacryptomerozoites
C. Merozoites
D. Trophozoites.

Answer

To answer the question "Malaria fever coincides with liberation of," we can follow these steps:

### Step-by-Step Solution:

1. **Identify the Causative Agent**:
- Malaria is caused by the protozoan parasite known as Plasmodium, specifically Plasmodium vivax in this context.

2. **Understand the Life Cycle**:
- The life cycle of Plasmodium involves several stages, including sporozoites, metacryptozoites, merozoites, and trophozoites. The sporozoites are introduced into the human bloodstream by the bite of an infected female Anopheles mosquito.

3. **Infection Process**:
- Once in the bloodstream, sporozoites travel to the liver, where they multiply and develop into metacryptozoites. These metacryptozoites then enter the bloodstream again.

4. **RBC Infection**:
- The metacryptozoites invade red blood cells (RBCs) and transform into merozoites. This stage is crucial as the merozoites multiply within the RBCs.

5. **Rupture of RBCs**:
- The multiplication of merozoites leads to the rupture of the RBCs. This rupture releases the merozoites back into the bloodstream.

6. **Toxin Release**:
- Along with the merozoites, the breakdown of hemoglobin within the RBCs releases a toxic substance called hemozoin. This hemozoin is responsible for triggering the fever associated with malaria.

7. **Conclusion**:
- Therefore, the liberation of merozoites and the associated hemozoin coincide with the onset of malaria fever. The recurrent nature of the fever is due to the cyclical rupture of RBCs every 48 to 72 hours.

### Final Answer:
Malaria fever coincides with the liberation of **merozoites**.

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