Which of the following is not of fungal origin

Options

A. Calvacin
B. Citric acid
C. Ergotamine
D. Tetracycline

Answer

To determine which of the following options is not of fungal origin, we will analyze each option one by one:

1. **Calvacin**: This is an anti-tumor mucoprotein that is derived from the fungus *Calvacea gigante*. Since it originates from a fungus, it is not the answer we are looking for.

2. **Citric Acid**: This compound is produced commercially and industrially using the fungus *Aspergillus niger*. Since it is derived from a fungus, this also does not fit our criteria.

3. **Ergotamine**: This compound is derived from ergot, which is a fungus. Therefore, it is also not the answer we are looking for.

4. **Tetracycline**: This is a broad-spectrum antibiotic that is derived from *Streptomyces*, which is a genus of bacteria, not a fungus. Hence, this option is not of fungal origin.

After analyzing all the options, we conclude that the correct answer is **Tetracycline**, as it is not derived from a fungus.

### Summary of the Solution:
- Calvacin: Fungal origin (from *Calvacea gigante*)
- Citric Acid: Fungal origin (from *Aspergillus niger*)
- Ergotamine: Fungal origin (from ergot)
- Tetracycline: Not of fungal origin (from *Streptomyces*)

**Final Answer: Tetracycline**

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