Reduction of ketones canot be carried out with which of the following reagents?

Options

A. Hydrogen in the presence of palladiun deposited over barium sulphate in the presence of quinoline
B. Sodium borohydride or lithium aluminimum hydride
C. Zinc amalgam and conc. HCl
D. Hydrazine and KOH in ethylene glycol.

Explanation

To determine which reagent cannot be used for the reduction of ketones, we need to analyze the options provided. Here’s a step-by-step solution:

### Step 1: Understand the Reduction of Ketones
Ketones can be reduced to secondary alcohols through various reducing agents. Common reducing agents include lithium aluminum hydride (LiAlH4), sodium borohydride (NaBH4), and catalytic hydrogenation.

### Step 2: Analyze Each Option
1. **Hydrogen in the presence of palladium deposited over barium sulfate in the presence of quinoline**: This is known as the Rosenmund reduction, which is typically used for the reduction of acid chlorides to aldehydes, not ketones. Therefore, this option cannot be used for the reduction of ketones.

2. **Zinc amalgam and concentrated HCl**: This is known as the Clemmensen reduction, which can reduce ketones to alkanes. Therefore, this option can be used for the reduction of ketones.

3. **Hydrogen and KOH in ethylene glycol**: This is the Oldfield-Kisner reduction, which can also reduce ketones. Therefore, this option can be used for the reduction of ketones.

### Step 3: Identify the Correct Answer
From the analysis, the only reagent that cannot be used for the reduction of ketones is the first option: **Hydrogen in the presence of palladium deposited over barium sulfate in the presence of quinoline**.

### Final Answer:
The reduction of ketones cannot be carried out with **Hydrogen in the presence of palladium deposited over barium sulfate in the presence of quinoline**.

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