Region of chromosome where force is exerted during chromatid separation is

Options

A. Telomere
B. Centromere
C. Chromomere
D. Chromonemate

Answer

To answer the question regarding the region of the chromosome where force is exerted during chromatid separation, we can follow these steps:

### Step-by-Step Solution:

1. **Understanding Chromatid Separation**: Chromatid separation occurs during the anaphase stage of cell division. During this phase, sister chromatids are pulled apart to opposite poles of the cell.

2. **Identifying Chromosome Structure**: Each chromosome consists of two sister chromatids that are joined together at a specific region. This region is crucial for the separation process.

3. **Identifying the Key Region**: The region where the sister chromatids are joined is known as the **centromere**. This is the point of attachment for the sister chromatids.

4. **Role of the Centromere**: The centromere is made up of contractile proteins and plays a vital role in the separation of chromatids. It is at this region that the spindle fibers attach.

5. **Kinetochore Function**: The kinetochore is a structure that forms at the centromere and is essential for the attachment of spindle fibers. The spindle fibers exert force on the chromatids through the kinetochore.

6. **Force Exertion**: When the spindle fibers contract, they create tension. This tension is what pulls the sister chromatids apart during anaphase, leading to their separation.

7. **Conclusion**: Therefore, the correct answer to the question is **centromere**, as it is the region where the force is exerted during chromatid separation.

### Final Answer:
The region of the chromosome where force is exerted during chromatid separation is the **centromere**.

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