Chromosomes appear beaded during

Options

A. Pachytene
B. Leptotene
C. Diakinesis
D. Diplotene

Answer

### Step-by-Step Solution:

1. **Understanding the Question**: The question asks during which stage of meiosis chromosomes appear beaded. The options provided are:
- Pachytene
- Leptotene
- Diakinesis
- Diplotene

2. **Identifying the Stages of Meiosis**:
- **Leptotene**: This is the first stage of prophase I of meiosis. During this stage, chromosomes begin to condense and become visible as thin threads. They appear beaded due to the presence of chromatin.
- **Pachytene**: This is the second stage of prophase I, where homologous chromosomes undergo crossing over.
- **Diplotene**: This is the fourth stage of prophase I, where the homologous chromosomes remain attached at points called chiasmata after crossing over has occurred.
- **Diakinesis**: This is the last stage of prophase I, where the chromosomes condense further and the nuclear envelope breaks down.

3. **Analyzing the Options**:
- The beaded appearance of chromosomes is specifically noted during the **Leptotene** stage, as they begin to condense and can be seen as distinct structures.

4. **Conclusion**: Based on the analysis, the correct answer to the question is **Leptotene**.

### Final Answer:
Chromosomes appear beaded during **Leptotene**.

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