Inner mitochodrial membrane allows the passage of

Options

A. Glucose
B. Pyruvate
C. NADH
D. Oxaloacetate

Answer

To determine what the inner mitochondrial membrane allows to pass through, we need to analyze the options given: glucose, pyruvate, NADH, and oxaloacetate.

### Step-by-Step Solution:

1. **Understanding the Role of the Inner Mitochondrial Membrane**:
- The inner mitochondrial membrane is crucial for cellular respiration. It is selectively permeable and plays a key role in the transport of metabolites and ions.

2. **Analyzing Each Option**:
- **Glucose**: Glucose is a large molecule and cannot pass through the inner mitochondrial membrane directly. It is broken down into smaller molecules (pyruvate) during glycolysis in the cytoplasm before entering the mitochondria.

- **Pyruvate**: Pyruvate is the end product of glycolysis. It is a smaller molecule compared to glucose and can be transported across the inner mitochondrial membrane into the mitochondrial matrix, where it undergoes further processing (oxidative decarboxylation) to form Acetyl CoA.

- **NADH**: NADH is a reduced coenzyme that carries electrons. It cannot directly cross the inner mitochondrial membrane. Instead, it participates in the electron transport chain within the membrane.

- **Oxaloacetate**: Oxaloacetate is an intermediate in the Krebs cycle. It is also not able to cross the inner mitochondrial membrane freely and is formed within the mitochondrial matrix.

3. **Conclusion**:
- Based on the analysis, the only molecule that can pass through the inner mitochondrial membrane is **pyruvate**. Therefore, the correct answer is **pyruvate (Option B)**.

### Final Answer:
The inner mitochondrial membrane allows the passage of **pyruvate**.

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