Pyruvate dehydrogenase complex needed for conversion of pyruvic acid to acetyl CoA is located in

Options

A. Intermembrane space
B. Cytoplasm
C. Matrix of mitochondira
D. Grana of chloroplast.

Answer

To determine where the pyruvate dehydrogenase complex (PDC) is located, we can follow these steps:

### Step-by-Step Solution:

1. **Understand the Function of Pyruvate Dehydrogenase Complex**:
- The PDC is responsible for converting pyruvic acid (pyruvate) into acetyl CoA, which is a crucial step in cellular respiration.

2. **Identify the Possible Locations**:
- The options provided are:
- Intermembrane space
- Cytoplasm
- Matrix of mitochondria
- Grana of chloroplast

3. **Analyze Each Option**:
- **Intermembrane Space**:
- The intermembrane space of mitochondria is not where the PDC operates. It is involved in the electron transport chain, not in the conversion of pyruvate.
- **Cytoplasm**:
- While glycolysis occurs in the cytoplasm, the PDC itself is not located here in eukaryotic cells. Prokaryotes have the PDC in the cytosol, but in eukaryotes, it is found elsewhere.
- **Matrix of Mitochondria**:
- The PDC is indeed located in the mitochondrial matrix in eukaryotic cells. This is where the conversion of pyruvate to acetyl CoA takes place.
- **Grana of Chloroplast**:
- The grana are involved in photosynthesis and do not participate in the respiration processes that involve pyruvate dehydrogenase.

4. **Conclusion**:
- Based on the analysis, the correct answer is that the pyruvate dehydrogenase complex needed for the conversion of pyruvic acid to acetyl CoA is located in the **matrix of mitochondria**.

### Final Answer:
The pyruvate dehydrogenase complex needed for the conversion of pyruvic acid to acetyl CoA is located in the **matrix of mitochondria**.