Juxtaglomerular apparatus is made up of

Options

A. Juxtaglomerular cell, macula densa and lacis cell
B. Juxtaglomerular cell, lacis cell and myoepithelial cell
C. Juxtaglomerular cell, lacis cell and Purkinje cell
D. Juxtaglomerular cell, macula densa and argentaffin cell

Answer

### Step-by-Step Solution:

1. **Understanding the Juxtaglomerular Apparatus (JGA)**:
- The Juxtaglomerular apparatus is a specialized structure located in the nephron, which is the functional unit of the kidney.

2. **Location**:
- The JGA is situated next to the glomerulus, which is a network of capillaries involved in the filtration of blood.

3. **Components of the JGA**:
- The JGA is composed of several specialized cells:
- **Juxtaglomerular Cells**: These are smooth muscle cells located in the walls of the afferent arterioles. They play a crucial role in regulating blood pressure by releasing renin.
- **Macula Densa**: This is a group of specialized cells located in the distal convoluted tubule (DCT) that sense sodium concentration and help regulate glomerular filtration rate and blood pressure.
- **Lacis Cells**: Also known as extraglomerular mesangial cells, these cells are located between the macula densa and the juxtaglomerular cells and are thought to play a role in communication and support within the JGA.

4. **Conclusion**:
- Therefore, the Juxtaglomerular apparatus is made up of:
- Juxtaglomerular cells
- Macula densa
- Lacis cells

5. **Final Answer**:
- The correct answer is that the Juxtaglomerular apparatus is made up of juxtaglomerular cells, macula densa, and lacis cells.