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Assertion : Hb^(5)Hb^(5) denotes the hom...

Assertion : `Hb^(5)Hb^(5)` denotes the homozygous condition for sickle-cell anaemia.
Reason : It occurs due to substitution of glutamic acid by valine at the `6^("th")` position of `beta` - chain of Hb.

A

A

B

B

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C

D

D

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Assertion: Hb^(S) Hb^(S) is homozygous condition of sickle cell anaemia. Reason: It occurs due to substitution of glutamic acid by valine at sixth position in beta -chain of haemoglobin.

The defect sickle-cell anaemia is caused by the "_____" of glutamic acid by the valine at the 6^(th) position of the "_____" globin chain of the haemoglobin molecule.

Read the following statement s and choose the correct option In phenylketonuria the affected person does not secrete the enzyme to convert phenylalanine to tyrosine (II)Possibility of male becoming haemophiliac is extremely rare (III) Sickle cell anaemia is caused by the substitution of glutamic acid by valine at fifth position of beta chain of haemoglobin (IV) Myotonic dystrophy is an autosomal dominant trait

Assertion :-Sickle-cell anaemia is caused by the substitution of glutamic acid by valine at the sixth position of the beta globin chain of the hemoglobin moecule. Reason :- It is due to the single base substitution at the sixth codon of the beta globin gene from GUG to GAG.

In sickle - cell anaemia , the defect is caused by the substitution of ……..(i) ……….by ………(ii) ………..in the ………(iii)………position of the beta - globin chain of the haemoglobin molecule.

In sickle cell anaemia, the sequence of amino acid from first to seventh position of beta -chain of haemoglobin S (HbS) is

In sickle cell anaemia, there is change in amino acid in beta chain at position

Read the following paragraph carefully and find out the correct words for all the three blanks indicated as (A) (B) and (C ) "the substitution of amino acid in the globin protein results due to the single base subsitution at the 6^(th) codon of the beta -globin gene from overset((A))("_____") to overset((B))("_____") . The mutant haemoglobin molecule undergoes polymerisation under overset((C))("_____") tension causing the change in the shape of the RBO from biconcave disc to elongated sickle-like structure.

[A]: Genetic disorder, sickle cell anaemia is common in new born babies· [R]: It is caused by heterozygosity for allble Hbc, producing a single ammo acid substitu tion in the a-chain of the Haemoglobin deter- mined by allele Hb^A

Assertion: The person heterozygous for sickle-cell trait produces both normal (Hb^A) and abnormal haemoglobin (Hb^S) . Reason: The normal allele and the sickle-allele are codominant.

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