With respect to phenyl ketouria indentify which statement is not correct

Options

A. It is an error in metabolism
B. Caused due to autosomal recessive trait
C. It is an example of pleiotropy
D. It is a case of aneuploidy

Answer

To answer the question regarding phenylketonuria (PKU) and identify which statement is not correct, we can follow these steps:

### Step-by-Step Solution:

1. **Understand Phenylketonuria (PKU)**:
- PKU is an inborn error of metabolism caused by a deficiency of the enzyme phenylalanine hydroxylase, which is responsible for converting the amino acid phenylalanine into tyrosine.

2. **Identify Key Characteristics of PKU**:
- It is classified as an autosomal recessive disorder. This means that an individual must inherit two copies of the mutated gene (one from each parent) to exhibit the disorder.
- PKU leads to the accumulation of phenylalanine in the body, which can cause serious health issues if not managed properly.

3. **Pleiotropic Effects**:
- The gene responsible for PKU has pleiotropic effects, meaning it can affect multiple traits or functions in the body.

4. **Analyze the Statements**:
- We need to evaluate the given statements about PKU:
- It is an inborn error of metabolism (True)
- It is caused by an autosomal recessive trait (True)
- It is an example of pleiotropy (True)
- It is a case of aneuploidy (Not True)

5. **Identify the Incorrect Statement**:
- The statement that PKU is a case of aneuploidy is incorrect. Aneuploidy refers to an abnormal number of chromosomes due to non-disjunction during cell division, which is not related to PKU.

### Conclusion:
The statement that is not correct with respect to phenylketonuria is that it is a case of aneuploidy.

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