In adolescents acne develop in

Options

A. Males in response to androgen
B. Females in response to oestrogen
C. Both males and females in response to androgen
D. Both males and females in response to oestrogen.

Answer

**Step-by-Step Solution:**

1. **Understanding the Question**: The question asks about the development of acne during adolescence and which group (males, females, or both) is affected by specific hormones.

2. **Identifying the Hormones**: The options provided mention two hormones: androgen and estrogen. It is important to understand the role of these hormones in the body, particularly during adolescence.

3. **Role of Estrogen**: Estrogen is primarily associated with female reproductive functions, including the regulation of the menstrual cycle. It does not have a direct link to the development of acne.

4. **Role of Androgen**: Androgens are hormones that contribute to growth and reproduction in both males and females. They are often referred to as male hormones, but females also produce them in smaller amounts. The main androgen related to acne is testosterone, specifically its derivative, dihydrotestosterone (DHT).

5. **Sebaceous Glands and Acne**: The sebaceous glands in the skin produce oil, and their activity is influenced by androgens. Increased androgen levels during puberty lead to heightened activity of these glands, which can result in acne.

6. **Conclusion**: Given that both males and females produce androgens and that these hormones are responsible for the development of acne during adolescence, the correct answer is that both males and females develop acne in response to androgens.

7. **Final Answer**: The correct option is: "both males and females in response to androgen."

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