In alcoholics, liver cells come to accumulate fat. Fat formation is stimulated by

Options

A. Alcohol
B. Acetaldehyde
C. Thiamine deficiency
D. Folic acid deficiency

Answer

To solve the question regarding the accumulation of fat in the liver cells of alcoholics and what stimulates this fat formation, we can follow these steps:

### Step-by-Step Solution:

1. **Understanding the Context**: The question is about alcoholics and the accumulation of fat in liver cells. This condition is often associated with fatty liver disease.

2. **Identifying the Process**: In the liver, alcohol is metabolized primarily by an enzyme called alcohol dehydrogenase. This enzyme converts alcohol into acetaldehyde.

3. **Role of Acetaldehyde**: Acetaldehyde is a toxic compound that can lead to various metabolic disturbances. One of the consequences of its accumulation is the stimulation of fat formation in liver cells.

4. **Fat Accumulation Mechanism**: The presence of acetaldehyde promotes the synthesis of fatty acids and inhibits their oxidation, leading to an increase in fat storage within liver cells.

5. **Evaluating the Options**: The options provided are:
- Alcohol
- Acetaldehyde
- Thiamine deficiency
- Folic acid deficiency

Among these, acetaldehyde is directly involved in the process of fat accumulation in the liver.

6. **Conclusion**: Therefore, the correct answer to the question is **acetaldehyde**, as it is the compound that stimulates fat formation in liver cells of alcoholics.

### Final Answer:
The fat formation in alcoholics is stimulated by **acetaldehyde**.

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