Mode of action of Novobiocin is

Options

A. Induces abnormal protein synthesis
B. Inhibits DNA polymerisation
C. Interferes with protein synthesis
D. Inhibits cell wall synthesis

Answer

### Step-by-Step Solution:

1. **Definition of Novobiocin**:
- Novobiocin is an antibiotic that is used to treat bacterial infections. It is derived from a specific type of bacteria known as *Streptomyces*.

2. **Source of Novobiocin**:
- This antibiotic is obtained from the bacterium *Streptomyces niveus*.

3. **Mode of Action**:
- The primary mode of action of novobiocin is that it acts as a DNA topoisomerase inhibitor.

4. **Role of DNA Topoisomerase**:
- DNA topoisomerase is an enzyme that plays a crucial role during DNA replication. It helps in unwinding the DNA strands, allowing for proper replication.

5. **Effect on Bacteria**:
- By inhibiting the DNA topoisomerase, novobiocin disrupts the process of DNA replication. This interference ultimately leads to the death of the bacteria, as they are unable to properly replicate their DNA.

6. **Conclusion**:
- Therefore, the mode of action of novobiocin is as a DNA topoisomerase inhibitor, which interferes with DNA polymerization and leads to bacterial cell death.