Secretion of pancreatic juice is stimulated by

Options

A. Enterokinase
B. Cholecystokinin
C. Trypsinogen
D. Secretin

Answer

**Step-by-Step Solution:**

1. **Understanding Pancreatic Juice**: Pancreatic juice is a digestive fluid produced by the pancreas that contains enzymes and bicarbonate. It plays a crucial role in the digestion of carbohydrates, proteins, and fats in the small intestine.

2. **Identifying Stimuli for Secretion**: The secretion of pancreatic juice is regulated by various hormones and factors. The key hormones involved include secretin, cholecystokinin (CCK), and others.

3. **Role of Secretin**: Secretin is a hormone released by the duodenum (the first part of the small intestine) in response to acidic chyme entering from the stomach. It stimulates the pancreas to release a watery, bicarbonate-rich fluid that neutralizes stomach acid, thus creating an optimal environment for digestive enzymes.

4. **Role of Cholecystokinin (CCK)**: CCK is another hormone that stimulates the pancreas to release digestive enzymes, but it primarily works on the enzymatic part of pancreatic juice rather than the non-enzymatic part.

5. **Other Options**:
- Enterokinase is an enzyme that activates trypsinogen to trypsin but does not directly stimulate pancreatic juice secretion.
- Trypsinogen is an inactive precursor of trypsin and is not responsible for stimulating the secretion of pancreatic juice.

6. **Conclusion**: Among the options provided, secretin is the most important hormone that stimulates the secretion of pancreatic juice, particularly the non-enzymatic component.

**Final Answer**: The secretion of pancreatic juice is stimulated by **D) Secretin**.

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