Thiamine `B_(1)` deficiency leads to

Options

A. Beri-beri
B. Scurvy
C. Night blindness
D. Pellagra

Answer

### Step-by-Step Solution:

1. **Understanding Thiamine (Vitamin B1)**:
- Thiamine, also known as Vitamin B1, is a water-soluble vitamin that plays a crucial role in carbohydrate metabolism. It is essential for converting carbohydrates into energy.

2. **Role of Thiamine in Energy Production**:
- Thiamine is converted into thiamine diphosphate (TPP), which is a coenzyme involved in the decarboxylation of pyruvate to acetyl-CoA, a key step in the Krebs cycle for ATP synthesis.

3. **Consequences of Thiamine Deficiency**:
- A deficiency in thiamine leads to impaired energy production, as the body cannot efficiently convert carbohydrates into energy. This can result in various neurological and muscular symptoms.

4. **Identifying the Condition**:
- The symptoms of thiamine deficiency include nerve conduction issues, muscle weakness, and loss of sensation. These symptoms are characteristic of a condition known as beriberi.

5. **Conclusion**:
- Among the options provided (beriberi, scurvy, night blindness, and pellagra), the correct answer is beriberi, as it is directly associated with thiamine deficiency.

### Final Answer:
Thiamine (B1) deficiency leads to **beriberi**.

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